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In the last few years, there has been considerable interest in restoring levels of the nicotinamide adenine dinucleotide (NAD+) coenzyme to combat age-related diseases. Evidence suggests that NAD+ systemically declines with age in a variety of organisms, which contributes to the development of many age-related diseases and metabolic conditions.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide.

 NAD+ in red, beta sheets in yellow, and alpha helices in purple.

NAD facilitates redox reactions, carrying electrons from one reaction to another. This means that NAD is found in two forms in the cell; NAD+ is an oxidizing agent that takes electrons from other molecules in order to become its reduced form, NADH. NADH can then become a reducing agent that donates the electrons it carries. The transfer of electrons is one of the main functions of NAD, though it also performs other cellular processes, including acting as a substrate for enzymes that add or remove chemical groups from proteins in post-translational modifications.

The coenzyme NAD+ was discovered by: British biochemists Arthur Harden and William John Young in 1906. 

They noticed that adding boiled and filtered yeast extract greatly accelerated alcoholic fermentation in unboiled yeast extracts. They called the unidentified factor responsible for this effect a coferment. Through a long and difficult purification from yeast extracts, this heat-stable factor was identified as a nucleotide sugar phosphate by Hans von Euler-Chelpin. In 1936, the German scientist Otto Heinrich Warburg showed the function of the nucleotide coenzyme in hydride transfer and identified the nicotinamide portion as the site of redox reactions.

Arthur Harden

William John Young

Vitamin precursors of NAD+ were first identified in 1938, when Conrad Elvehjem showed that liver has an "anti-black tongue" activity in the form of nicotinamide. Then, in 1939, he provided the first strong evidence that niacin is used to synthesize NAD+. In the early 1940s, Arthur Kornberg was the first to detect an enzyme in the biosynthetic pathway. In 1949, the American biochemists Morris Friedkin and Albert L. Lehninger proved that NADH linked metabolic pathways such as the citric acid cycle with the synthesis of ATP in oxidative phosphorylation. In 1958, Jack Preiss and Philip Handler discovered the intermediates and enzymes involved in the biosynthesis of NAD+ salvage synthesis from nicotinic acid is termed the Preiss-Handler pathway. In 2004, Charles Brenner and co-workers uncovered the nicotinamide riboside kinase pathway to NAD+.

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NMN PLUS PREMIUM FORMULA
  • NMN Plus Supplement is the most Powerful NAD+ Precursor.

  • 3rd Part Lab Tested - NMN PLUS 3rd Party Independent Lab Tested

  • NAD+ Precursor - NNM Plus Nicotinamide Mononucleotide is derivative of the Vitamin B-3 (Niacin) - which is acting as precursor of NAD+ which plays a crucial role in energy production, metabolism, and gene expression in the body.

  • No Artificial Color, Flavor or Sweetener, No Preservatives, 100%  Fruits extracts.

Botanical Beverage Mix

  • Avocado and Red beet with Avocado extract. 

  • Natural bioactive NMN from fruit

  • + avocado extract (nicotinamide mononucleotide)

  • + red beet & avocado ( source of nitrate  oxide )

  • + mulberry extract ( anthocyanin)

Serving:
Consume directly from the sachet or mix with water. Take 1-2 sticks daily recommended. 

Excellent product quality according to international GMP standards. 

BENEFITS

  • Cellular Repair & Energize Energy & Stamina

  • Reverse and anti aging

  •  Lower LDL Cholesterol

  • Prevent Cancer growth

  • Increases HDL Cholesterol  - Studies show that NAD raises HDL levels by 15–35%

  • NAD can also lower triglycerides by 20–50% 

  • Prevent Heart Disease - NAD+ effect on cholesterol may help prevent heart disease — but newer research suggests an additional mechanism by which it benefits your heart.

  • Help Treat Type 1 Diabetes - Type 1 diabetes is an autoimmune disease in which your body attacks and destroys insulin-creating cells in your pancreas.

  • Boosts Brain Function - Your brain needs niacin — as a part of the coenzymes NAD and NADP — to get energy and function properly.

  • Improves Skin Function - NAD+ helps protect skin cells from sun damage, whether it's used orally or applied as a lotion.  Recent research suggests it may help prevent some types of skin cancer as well

  • Reduce Symptoms of Arthritis - In one preliminary study, NAD helped ease some symptoms of osteoarthritis, improving joint mobility and reducing the need for nonsteroidal anti-inflammatory drugs